The aim of present investigation was to develop and evaluate bilayer sustained release tablets of Diltiazem hydrochloride (DTZ) .The bilayer sustained release tablets were prepared by wet granulation. Polyox WSR 303 and HPMC K15M were used as hydrophilic polymers. Superdisintegrant was incorporated into the formulations to release fastly loading dose from the dosage form. The amount of polymer blends was optimized using 32 full factorial design. The prepared bilayer tablets were evaluated for disintegration time, swelling study, hardness, friability, drug content and in-vitro release. More than 90% of Diltiazem drug was released within 1 hour. HPMC K15M and polyox WSR 303 sustained the release of Diltiazem hydrochloride from the sustained release layer for 12 hrs. Diffusion exponents (n) were determined for optimized formulation (<0.5).So, predominant drug release mechanism is Fickian diffusion mechanism. The stability study showed no significant change in appearance of tablets, drug content and dissolution profile. Therefore, biphasic drug release pattern was successfully achieved through the formulation of bilayer sustained release tablets.
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